ICMRS Scientific Frontier Webinar Series

The new concept of “Aging microenvironment” and musculoskeletal system organ degeneration

Presented by Xiaoling Zhang, Ph.D.

Professor and Director, Stem cells and regeneration medicine Laboratory, Xinhua Hospital,

Shanghai Jiao Tong University School of Medicine

When: July 4, 2020 (Saturday) 9:00 PM Eastern Time (US and Canada)

July 4, 2020 (Saturday) 8:00 PM Central Time (US and Canada)

2020年7月5日（星期日）北京时间上午9:00 （中国）

July 5, 2020 (Sunday) 9:00 AM Perth (Australia - Western Australia)

July 5, 2020 (Sunday) 11:00 AM Sydney (Australia - New South Wales)

Short Biography: Xiaoling Zhang, Professor and Director, Stem cells and regeneration medicine Laboratory, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine. Dr. Zhang’s research mainly focuses on: 1) Organ degeneration mechanism of musculoskeletal system and prevention strategy; 2) Stem cell and regeneration regulation of bone and joint. Dr. Zhang has got more than 30 important project supports as PI from Ministry of Science and Technology of China and National Natural Science Foundation of China, including science and technology major projects of China, key projects of national natural Science Foundation of China, stem cell pilot project of Chinese Academy of Sciences, etc. She is fellow of ICORS (international combined orthopaedic research society), She has got six talent training programs, including "Outstanding Youth of Chinese Academy of Sciences" and "Outstanding Academic Leaders of Shanghai". She served as chairman of China Development Committee (2019-2021) and chairman of woman Committee (2013-2015) of ICMRS (international Chinese musculoskeletal research Society), Dr. Zhang is the editor-in-chief of Cases in orthopaedic research. Dr. Zhang has authored over 100 scientific papers including some in Ann Rheum Dis、J Bone Miner Res、Biomaterials. Her papers have been cited more than 3500 times, H-index 36. She has got over 20 academic awards, such as Best Paper Awards for Young Investigator of 29th FIMS World congress of Sport Medicine (2006), Best prize in orthopedics basic research of The 10th International Congress of Chinese Orthopaedic Association (2015).

简介：张晓玲，上海交通大学医学院附属新华医院研究员，博士生导师。研究方向：1）骨骼肌肉系统器官退变机制及防治策略； 2）干细胞及骨关节再生调控。已作为项目负责人承担国家科技重大专项、国家自然基金重点项目、中科院干细胞先导专项等30余项重要科技任务。被评为国际联合骨科研究学会会士（ICORS Fellow），入选 “中国科学院优秀青年”、“上海市优秀学术带头人”等6项省部级人才培养计划。任国际华人肌骨骼研究学会（ICMRS）中国委员会主席（2019-2021）、女委员会主席（2013-2015）；Cases Ortho Res主编等学术职务。在Ann Rheum Dis、J Bone Miner Res、Biomaterials等领域一流期刊发表SCI论文100余篇，论文他引3500余次，H-index 36，获国际运动医学学会最优秀青年学者论文奖、国际COA学术大会骨基础研究一等奖等20余项科技学术奖项。

Abstract: Professor Zhang Xiaoling's team found that “imbalance of immune homeostasis”, “senescent cells accumulation” and “stem cells exhaustion” led to organ degeneration, based on the clinical and basic research of aging diseases of musculoskeletal system. So far, there is no effective strategy to prevent organ aging in clinic. The new concept of "aging microenvironment" is of great significance for understanding organ aging. Comprehensive interpretation of the changes of cells composition (stem cells, immune cells, Senescent cells) and gene expression in various types of cells in "aging microenvironment", Screening and identification of the novel cell and molecular targets that lead to imbalance of tissue and organ homeostasis, will be the research direction of aging diseases of musculoskeletal system.

摘要：张晓玲教授团队在骨骼肌肉系统器官衰老性疾病的临床及基础研究中发现：自身免疫稳态失衡、衰老细胞堆积和干细胞耗竭导致器官功能退变。目前临床上尚未建立有效的防治器官衰老的方法。“衰老微环境”新概念的提出对解析器官衰老有重要意义。全面解读“衰老微环境”中细胞类型（干细胞、免疫细胞等）组成的变化以及各类细胞内基因表达变化，筛选和鉴定导致组织器官稳态失衡的新型细胞和分子靶标，将是骨骼肌肉系统器官衰老性疾病研究的方向。

This webinar will be moderated by Dr. Shuying Yang, Associate Professor, University of Pennsylvania School of Dental Medicine.

If you are not able to attend ICMRS webinars, you are welcome to click here for recorded videos from ICMRS Scientific Frontier Webinar Series.

For more information, please contact:

Jean Jiang, PhD

Chair, Education Committee, ICMRS

Professor and Zachry Distinguished University Chair

Department of Biochemistry and Structural Biology

University of Texas Health Science Center at San Antonio